Publishes practicechanging clinical cancer research and is the authoritative source for current information on the diagnosis and treatment of patients with cancer. Preclinical cellculture and animalmodel work has identified the role of the androgen receptor ar signaling pathway as a potential driver of tumor growth in this subset of cancers. D1067v might function as a novel tumorpromoting genetic alteration, and potentially an oncogene, in certain cancers. Although somatic mutations in the pi3k pathway genes pik3ca and pten are known to drive. Petros giannikopoulos, and driver s lead investor is horizons ventures li ka shing. William polkinghorn, md san francisco, ca doximity. Driver s lead investor is horizons ventures li ka shing. He speaks with bloombergs stephen engle on bloomberg. Sep 06, 2018 drivers polkinghorn was a radiation oncologist at memorial sloankettering, one of the biggest cancer treatments centers in the u. Nonmember subscribers have online access to tables of contents, abstracts, fulltext searching, fulltext display, podcasts, document delivery, pdfs, links to medline and genbank, future tables of contents. Sep 06, 2018 one of the projects that driver is fully funding under the program has begun matching patients being treated at howard university to clinical trials at ncis inhouse cancer center in bethesda, md. Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. Our ceo and cofounder, will polkinghorn, will kick off the night with an introduction to driver before our head of engineering, nathan boley and a few of our technical leads and engineers dive into the tech talk.
There is an air gap between knowledge and patients that has existed in cancer care since the 1850s, said driver cofounder will polkinghorn. The global tech platform aiming to revamp cancer care. Oct 19, 2018 driver has also created a parallel app for oncologists, called drive for clinic, so they can easily access the latest research and treatment options by colleagues around the world. Sequencing of prostate cancers identifies new cancer genes. On the basis of this finding, we hypothesized that pik3c. Can this app help chinas forgotten cancer sufferers. Polkinghorn, a radiation oncologist by training who was previously on the faculty of memorial sloan kettering cancer center, cofounded driver in may 2015 with an old harvard medical. Driver, a startup seeking to connect patients with clinical. Driver is a technology platform that connects people to treatments and.
One of the projects that driver is fully funding under the program has begun matching patients being treated at howard university to clinical trials at ncis inhouse cancer center in. When doctorsturnedentrepreneurs petros giannikopoulos and will polkinghorn were looking for a foothold in the bay area this past spring to test their startup, which connects cancer patients with. Driver, a startup seeking to connect patients with clinical trials, shuts. He graduated from case western reserve u, school of medicine in 1984 and specializes in medical oncology. Polkinghorn is on doximity as a doximity member youll join over a million verified healthcare professionals in a private, secure network. Medulloblastoma does not change subgroup at the time of recurrence, reinforcing the stability of the four main medulloblastoma subgroups. The clinicaltrialmatching startup driver shut down on oct. For cao ruizhe, the life or death drama of her fight with cancer plays out in a small windowless room. William polkinghorn, a former faculty member of memorial sloan kettering cancer center, told stat that the companys early reliance on directtoconsumer sales didnt yield enough revenue to keep drivers business afloat, or inspire enough confidence among investors to secure another funding round. Confirmed and durable responses to multikinase inhibitors with activity against ret can be achieved in a proportion of patients with retrearranged or retmutant cancers. Although somatic mutations in the pi3k pathway genes pik3ca and pten are known to drive pi3k pathway activation and cancer growth, the significance of somatic mutations in other pi3k pathway genes is less clear.
American society of clinical oncology 2020 publications and. Apr 16, 2018 prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. Drivers polkinghorn was a radiation oncologist at memorial sloankettering, one of the biggest cancer treatments centers in the u. He graduated from case western reserve u, school of medicine in 1984 and specializes in. Significant differences in the location and timing of recurrence. Polkinghorn is ceo at and has ownership interest including patents in driver group. Androgen receptor signaling regulates dna repair in prostate. Philadelphia, pa developing a more robust approach to measure mutational burden is of central importance to improving the characterization of the molecular profile of tumor and may improve our ability to predict tumor progression or response to therapy in patients. With an app for the patient and an app for the doctor, drivers platform enables any cancer patient. Sep 07, 2018 will polkinghorn, cofounder and chief executive officer of driver, explains how the company aims to revamp cancer care. A second opinion on a cancer diagnosis, from the comforts. Driver s polkinghorn was a radiation oncologist at. Pete has worked with a number of state and nationally ranked players. Is driver a story of fast fail or a cautionary tale against pursuing dtc.
American society of clinical oncology 2020 publications. Special member rates apply to member in training, allied physiciandoctoral scientist, affiliated health professional, and studentnononcology resident members. William polkinghorn radiation oncology resident memorial. Doctors backed by billionaire try cancer care revamp the star. Jak genes are the primary kinases that are found to be mutated. We demonstrate that the androgen receptor ar regulates a transcriptional program of dna repair genes. Polkinghorn says the problem with cancer treatment is that patients are limited by whatever diagnoses and treatment options are presented to them at whatever hospital they choose to go to. Androgen receptor signaling regulates dna repair in. Based in san francisco and shanghai, driver is a technology platform that connects cancer patients to treatments and knowledge, all over the world, to get more life. Activating alterations of the ret kinase are therapeutically actionable oncogenic drivers across a variety of cancers. May 18, 2015 integrative genomic approaches identify ikbke as a breast cancer oncogene. Will polkinghorn, cofounder and chief executive officer of driver, explains how the company aims to revamp cancer care.
New global technology platform, driver, launches to connect. Drivers highcost cancer care procurement app shutters. Oct 15, 2018 based in san francisco and shanghai, driver is a technology platform that connects cancer patients to treatments and knowledge, all over the world, to get more life. Significant differences in the location and timing of recurrence across medulloblastoma subgroups have potential treatment ramifications. We demonstrate that the androgen receptor ar regulates a transcriptional program of dna repair genes that promotes prostate cancer radioresistance, providing a potential mechanism by which androgen deprivation therapy synergizes with ionizing radiation. Drivers lead investor is horizons ventures li ka shing. Driver, a startup seeking to connect patients with. He speaks with bloombergs stephen engle on bloomberg technology. Androgen receptor upregulation mediates radioresistance. Recurrence patterns across medulloblastoma subgroups. The global tech platform aiming to revamp cancer care bloomberg. Based in san francisco and shanghai, driver is a technology platform that connects cancer patients to treatments and knowledge, all over the world, to get more. Activating point mutations in kinase genes are uncommon in highrisk ball. Petros giannikopoulos, and is the first technology platform to colaunch in the united states and china.
Mar 03, 2016 activation of the phosphoinositide 3kinase pi3k pathway occurs widely in human cancers. Harvard doctors backed by li kashing try a fix for cancer. Integrative genomic approaches identify ikbke as a breast cancer oncogene. Sawyers has provided expert testimony for coinventor of mdv3100 enzalutamide and is entitled to royalties.
Petros giannikopoulos, and drivers lead investor is horizons ventures li ka shing. D1067v by exome sequencing analysis of an egfrmutant nonsmall cell lung cancer nsclc tumor biopsy from a patient with acquired erlotinib resistance. Helen diller comprehensive cancer center, university of california, san francisco, san francisco, ca, usa. Driver has also created a parallel app for oncologists, called drive for clinic, so they can easily access the latest research and treatment options by colleagues around the world. Mar 21, 2019 there is an air gap between knowledge and patients that has existed in cancer care since the 1850s, said driver cofounder will polkinghorn. Sutcliffe mj, shuster jj, sather hn, et al high concordance from independent studies by the childrens cancer group ccg and pediatric oncology group pog associating favorable prognosis with combined trisomies 4, 10, and 17 in children with nci standardrisk bprecursor acute lymphoblastic leukemia. A second opinion on a cancer diagnosis, from the comforts of. The platform, called driver, was founded in 2015 by two american physicians, william polkinghorn and petros giannikopoulos, with headquarters in both shanghai and san francisco.
Research at memorial sloan kettering cancer center mskcc has identified a subset of tnbc, which appears to have a similar underlying biology as er breast cancer. Driver s polkinghorn was a radiation oncologist at memorial sloankettering, one of the biggest cancer treatments centers in the u. Tindall reports receiving commercial research grant from beckman coulter. A macmillian nurse later visited mum and the driver was changed to also include antisickness drugs as well as the pain releif and then within about 45 hours mum had passed away. William polkinghorn, a former faculty member of memorial sloan kettering cancer center, told stat that the. Full membership includes the jco and international corresponding members receive online access. Nov 12, 2018 polkinghorn, a radiation oncologist by training who was previously on the faculty of memorial sloan kettering cancer center, cofounded driver in may 2015 with an old harvard medical school. Specifically, intensified local posterior fossa therapy should be tested in the initial treatment of patients with shh. Our ceo and cofounder, will polkinghorn, will kick off the night with an introduction to driver before our head of engineering, nathan boley and a few of our technical leads and engineers dive into the tech. With bigname backing, driver launches to match cancer.
New global technology platform, driver, launches to connect cancer. Drivers network includes over 30 of the worlds leading cancer centers, including its founding members the. G polkinghorn, md is a medical oncology specialist in augusta, me and has been practicing for 36 years. Philadelphia, pa developing a more robust approach to measure mutational burden is of central importance to. These mutations are generally observed in patients with phlike all that have crlf2 abnormalities, although jak2 mutations are also observed in approximately 15% of children with down syndrome all. How curing cancer has become a machine learning problem nathan boley, head of engineering. Mutational burden is typically calculated as a direct enumeration. Pete polkinghorn joined the tennis staff in may of 2009 as the centers head tennis professional. William polkinghorn, md is a radiation oncologist in san francisco, california. The company not only collected tumor samples to be sequenced and. Drivers highcost cancer care procurement app shutters shortly after.
At last, an agreement to buy athenahealth politico. New global technology platform, driver, launches to connect cancer patients to the best treatments around the world. Polkinghorn is on doximity as a doximity member youll join over a million verified healthcare. Cancer clinical trials tech startup driver shutters two months. Mum was under hospital admission when she passed, however the day she died, the staff administrated a morphine syringe driver into the thigh. Childhood cancer genomics pdqhealth professional version. Advertise partner with us stat plus group subscriptions stat madness. Technology platform offers new options to cancer patients.
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